PARIS - Nine-time champion Rafael Nadal and top seeds Novak Djokovic and Serena Williams target places in the French Open third round on Thursday.
Nadal faces Nicolas Almagro boasting a 12-1 career advantage over his fellow Spaniard but wary of the danger posed by a man who beat him on clay in Barcelona only last year.
World number one Djokovic tackles Luxembourg's 55th-ranked Gilles Muller who he defeated in their only previous meeting at the Australian Open in January this year as the Serb went on to claim a fifth title in Melboune.
Djokovic is seeking a first French Open title which would make him just the eighth man to complete the career Grand Slam.
Britain's third seed Andy Murray, twice a semi-finalist in Paris, faces Portugal's Joao Sousa defending a 5-0 career record.
However, all of those meetings came on hard courts.
Women's top seed Serena Williams, a two-time champion, should have few problems against Anna-Lena Friedsam, the world number 105 player from Germany.
The two women have never met before.