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The Straits Times' Twitter account - @STcom - is the most followed account by users in Singapore.
Launched in May 2009, @STcom is No.1 in Singapore with 291,000 followers, as of Thursday.
It beat Twitter accounts such as The Ellen Show (in second place) and celebrities like Taylor Swift (fourth) and Katy Perry (fifth) in capturing the interest of Singapore users.
It is also the top Singapore-based account, beating other local accounts such as that of news organisation Channel NewsAsia (in second place), local blogger Xiaxue (third) and humour site So Singaporean (fourth).
Straits Times editor Warren Fernandez said: "We are striving to deliver on our promise to get the latest news and insights to ST readers wherever they are and whenever they want it.
"This means doing so online and via mobile, on social media like Twitter, Facebook and others, as well as in print, so being named No.1 on Twitter among Singaporeans is a great boon and will encourage us to keep at it."
More than 80 per cent of those who follow @STcom are from Singapore. This comes up to about 232,600 users, or about 9 per cent of the estimated 2.56 million Twitter users in Singapore.
Users from the region, including Malaysia and Indonesia, also contribute to ST's following.
The ranking was released by Twitter as part of the United States-based social media platform's eighth anniversary. It also released ranking lists in other countries, including Australia, South Korea and Japan.
Twitter is estimated to have 241 million active users globally.
Mr Parminder Singh, Twitter's managing director for South-east Asia, India, Middle East and North Africa, said: "Singaporeans are busy people and love to know what is happening in real time...
"So, it is no surprise that they love to follow the local news media on Twitter and why checking news is one of the top daily behaviours on our platform by Singaporeans."
The most popular tweet by ST was made during the severe haze last year. "#SGHaze update: PSI is 321 at 10.55pm @NEAsg" was retweeted 3,392 times.
A post with a photo of babies saw 3,054 retweets: "Hospital wraps newborns in #Christmas stockings."
More recently, "#Singapore sends C130 aircraft to search for missing #MAS aircraft http:// bit.ly/1ffawHJ #MH370 #MalaysiaAirlines" was retweeted 2,774 times.