The owners had moved out, leaving the dog alone in the terrace house along Ceylon Road.
A handwritten sign was left on the gate, with the words: "Whoever wants to adopt the dog, please look for me (maid from next door)."
On Tuesday, a netizen posted about the dog's plight, sharing it on Facebook, where it garnered more than 650 shares.
When The New Paper visited the house on Wednesday, the dog had been taken away, along with the sign.
The dog is now in a foster home, arranged by the Society for the Prevention of Cruelty to Animals (SPCA).
It is not clear how long the dog had been left alone in the house.
One neighbour, who wanted to be known only as Madam Chua, 72, estimated that it had been crying for its owners for almost a week.
She said: "The dog was very pitiful. Sometimes it would sniff the yard for its owners. It was very noisy as well. It would howl a lot at night."
The domestic helper from next door, who had posted the sign, told TNP that she had been feeding the dog with food left by its previous owners and some donated by neighbours.
The SPCA said in a Facebook post on Thursday that the owners had advertised their dog for rehoming on its notice board before they moved out of their home.
Ms Corrine Fong, the executive director of SPCA, told TNP that it was not a case of abandonment.
She said: "The dog was surrendered to the SPCA on Dec 2. The owners had also asked the domestic helper next door to help look after it."
When TNP spoke to the owners, who declined to be named, they said that they were sad to have left the dog behind.
One of the owners said: "We had the dog for eight years. We were unable to bring it along with us because we were moving to a smaller property."
Netizens, however, were outraged that the dog had been left alone.
Ms Angelia Long said on the Facebook page where photos of the dog had been posted: "What kind of people are these? Devils?"
Said another netizen Jenny Tan: "Super irresponsible owner!"
Mr Ricky Yeo, president of animal welfare group Action for Singapore Dogs, said: "Technically, it is abandonment.
"When you have ownership over a pet, you have to exercise responsibility of care for the pet - unless the owners have a standing agreement with their neighbours to look after it for a specified or indefinite period."
An Agri-Food and Veterinary Authority of Singapore spokesman told TNP that the agency is looking into the case.
This article was first published on Dec 6, 2014. Get The New Paper for more stories.