Blood test for early detection of gastric cancer could be available by year-end

Blood test for early detection of gastric cancer could be available by year-end
Associate Professor Yeoh Khay Guan of the Yong Loo Lin School of Medicine at the National University of Singapore said the non-invasive blood test will greatly simplify the diagnosis of gastric cancer and allow for early intervention.
PHOTO: The Straits Times

SINGAPORE - A blood test for detecting gastric cancer early may be available by the end of this year.

If approved by the Health Sciences Authority, it will be the first such test in the world, according to the expert leading the project.

"Gastric cancer is a silent killer as it is often detected late, making it harder to treat and cure," said Associate Professor Yeoh Khay Guan of the Yong Loo Lin School of Medicine at the National University of Singapore.

"This non-invasive blood test will greatly simplify the diagnosis of gastric cancer and allow for early intervention."

Gastric cancer is the fifth most common form of cancer, with about a million new cases being diagnosed a year worldwide. It is usually detected by endoscopy, which involves inserting a thin tube with a camera at the end into a patient's stomach.

"Currently there is no reliable blood test for the diagnosis of gastric cancer. Our test, if approved, will be the first blood-based test for detection of gastric cancer in the world," said Prof Yeoh.

The blood test works by measuring levels of micro-RNA, which help regulate genes. It is cheaper than endoscopy and results can be received on the same day.

The project, led by Prof Yeoh under the Singapore Gastric Cancer Consortium (SGCC), was one of four projects which received a grant from the National Medical Research Council (NMRC) on Wednesday (April 3).

A total of $82 million was awarded to the projects under the Open Fund Large Collaborative Grants programme.

This is the highest amount given in a single grant call since the programme was launched in 2016, said Health Minister Gan Kim Yong, who was the guest of honour at the awards ceremony at One Farrer Hotel.

The SGCC was awarded a $25 million grant. It had previously received a total of $50 million in government grants in 2007 and 2013.

Another project awarded $25 million was the Singapore Parkinson's Disease Translational Clinical Programme.

Led by Prof Tan Eng King from the National Neuroscience Institute, the project aims to identify risk factors and develop new drugs to treat Parkinson's Disease, which affects three in 1,000 people in Singapore aged 50 and above.

The team is also working on using stem cell transplants to replace nerve cells lost in the brain as a result of the disease, Prof Tan said.

The Singapore Lymphoma Translational Study was given $10 million, and a project on precision medicine for cardiovascular disease and diabetes in Asian populations was awarded $22 million.

Said Mr Gan: "Scientific discoveries and new research evidence are fundamental in the development of medical innovations that can translate into better clinical practices and policies, leading ultimately to improved patient care and better health for Singaporeans."

This article was first published in The Straits Times. Permission required for reproduction.

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