Many cases in the current monkeypox outbreak, largely centred on Europe, are among sexual partners who have had close contact, and the agency reiterated that virus is mainly transmitted via close interpersonal contact.
In recent days, scientists say they have detected viral DNA in the semen of a handful of monkeypox patients in Italy and Germany, including a lab-tested sample that suggested the virus found in the semen of a single patient was capable of infecting another person and replicating.
Catherine Smallwood, monkeypox incident manager at WHO/Europe, said it was not known whether recent reports meant the monkeypox virus could be sexually transmitted.
"This may have been something that we were unaware of in this disease before," she told a press briefing.
"We really need to focus on the most frequent mode of transmission and we clearly see that to be associated with skin to skin contact."
More than 1,300 cases of the viral disease have been reported by about 30 countries since early May. Most cases have been reported in men who have sex with men.
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The outbreak has triggered concern since the virus is rarely seen outside of Africa, where it is endemic, and the majority of the European cases are not related to travel to the continent.
As the outbreak spreads, the WHO has recommended targeted vaccination of close contacts, including healthcare workers, but has warned it is already seeing a rush to stockpile vaccines.
"Once again, a 'me first' approach could lead to damaging consequences down the road," said Hans Kluge, WHO's regional director for Europe.
"I beseech governments to tackle monkeypox without repeating the mistakes of the pandemic — and keeping equity at the heart of all we do."
